Breast cancer is the most common cancer in women and autologous fat grafting is an important clinical application in treatment of post-surgical deformities. The simplicity of fat grafting procedures and the absence of subsequent visible scar prompted an increasing interest for this technique. The plasticity of adipose-derived stem cells (ASCs) obtained from stromal vascular fraction (SVF) of adult adipose tissue provided exciting perspectives for regenerative medicine and surgery. The recent discovery that SVF/ASC enrichment further ameliorates clinical efficacy of grafting ASCs suggest as ASC-mediated new adipogenesis and vasculogenesis. ASC adipogenic differentiation involves Akt activity and EGFRs, FGFRs, ERbB2 receptor-mediated pathways that also play a pivotal role in the regulation of breast cancer growth. Moreover, the finding that platelet-derived growth factors and hormones improved long-term maintenance of fat grafting raises new concerns for their use during breast reconstruction after cancer surgery. However, it remains unclear whether grafted or resident ASCs may increase the risk of de novo cancer development or recurrence. Preliminary follow-up studies seem to support the efficacy and safety of SVF/ASCs enrichment and the additional benefit from the combined use of autologous platelet-derived growth factors and hormones during breast reconstruction procedures. In the present review we highlighted the complex interplay between resident or grafted ASCs, mature adipocytes, dormant or active breast cancer cells and tumor microenvironment. Actually, data concerning the permissive role of ASCs on breast cancer progression are contrasting, although no clear evidence speaking against their use exists.
Adipose-derived stem cells enhance human breast cancer growth and cancer stem cell-like properties through adipsin
PDF) Adipose tissue-derived mesenchymal stem cells for breast tissue regeneration
Frontiers Engineering Breast Cancer Microenvironments and 3D Bioprinting
Adipose-derived stem cell exosomes promote tumor characterization and immunosuppressive microenvironment in breast cancer
Engineering Breast Cancer Microenvironments and 3D Bioprinting. - Abstract - Europe PMC
Dr. Joel Aronowitz — Mechanical versus enzymatic isolation of stromal vascular fraction cells from adipose tissue, by Dr. Joel Aronowitz
The regenerative role of adipose‐derived stem cells (ADSC) in plastic and reconstructive surgery - Naderi - 2017 - International Wound Journal - Wiley Online Library
Fat Grafting in Breast Reconstruction
Adipose tissue engineering - ScienceDirect
Fat Grafting in Breast Reconstruction